Inspired by a spiritual understanding of ecology, we are establishing an Indigenous-led ethnobotanical initiative in which sustainability and economic justice come together to trigger a long-term process to incentivize reforestation as an avenue for development, Indigenous autonomy, and social change. Regenerative agroforestry techniques are piloted to be eventually adopted on deforested territories, replanted with specimens that can generate non-timber forest products with medicinal and cosmetic applications through harmless harvest. Such novel approach toward Indigenous co-operative entrepreneurship creates a tangible solution to heal Indigenous territories from the wounds of extractivism, through an economically fruitful proposal that ultimately furthers Indigenous territorial sovereignty and the Amazon’s future environmental health. Shipibo women-held plant knowledge, it becomes clear that non-timber forest products are higher in value than the price of the logs and the monocrops the Amazon is destroyed for. Reconciling sustainable development and conservation through a market solution, reforestation becomes an economically motivating force. At the heart of this initiative are deforested territories replanted adopting syntropic farming techniques.